منابع مشابه
Specific tandem GG to TT base substitutions induced by acetaldehyde are due to intra-strand crosslinks between adjacent guanine bases.
Acetaldehyde is present in tobacco smoke and automotive exhaust gases, is produced by the oxidation of ethanol, and causes respiratory organ cancers in animals. We show both the types and spectra of acetaldehyde-induced mutations in supF genes in double- and single-stranded shuttle vector plasmids replicated in human cells. Of the 101 mutants obtained from the double-stranded plasmids, 63% had ...
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The accurate interpretation of laboratory tests in patients with acid-base disorders is critical for understanding pathophysiology, making a diagnosis, planning effective treatment and monitoring progress. This is an important topic particularly for junior medical staff who may encounter acidbase problems outside normal working hours when patients become acutely unwell. These clinical situation...
متن کاملCharacterization of single base substitutions in edited apolipoprotein B transcripts.
Mature RNA transcripts from a single eukaryotic gene may contain different nucleotide sequences, ranging from alternately spliced exons to transcripts from separate alleles differing by only one base. Our laboratory and others have recently reported another class of RNA sequence differences, occurring in transcripts from the single copy apolipoprotein B (apoB) gene. A unique RNA editing mechani...
متن کاملEvolution models with base substitutions, insertions, deletions, and selection.
The evolution model with parallel mutation-selection scheme is solved for the case when selection is accompanied by base substitutions, insertions, and deletions. The fitness is assumed to be either a single-peak function (i.e., having one finite discontinuity) or a smooth function of the Hamming distance from the reference sequence. The mean fitness is calculated exactly in large-genome limit....
متن کاملSingle base substitutions are detected by double strand conformation analysis.
Fawzy A.Saad'-*, Birgit Halliger, Clemens R.Muller, Roland G.Roberts and Gian A.Danieli department of Biology, Padua School of Medicine, Via Trieste 75, 1-35121 Padova, Italy, department of Genetics, Sakha Road, ET-33516 Kafr El Shiekh, Egypt, department of Human Genetics, University of Wurzburg, D-97074 Wurzburg, Germany, Paediatric Research Unit, Division of Medical and Molecular Genetics, Un...
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ژورنال
عنوان ژورنال: Human Mutation
سال: 2013
ISSN: 1059-7794
DOI: 10.1002/humu.22192